Physiological angiogenesis is a graded, not threshold, response

Tackling HIV in MENA: Talk Is Not Enough–It Is Time for Bold Actions: A Response to Recent Commentaries

Angiostatin inhibits pathological but not physiological retinal angiogenesis.

PURPOSE Antiangiogenic treatment is a promising new therapy for angiogenesis-dependent diseases. In the current study, the biologic effects on pathologic and physiological angiogenesis in the retina of angiostatin, a very potent angiogenesis inhibitor were determined. In addition, the effects of angiostatin on the growth and development of newborn mice were examined. METHODS Oxygen-induced re...

Negative selection, not receptor editing, is a physiological response of autoreactive thymocytes

Antigen receptor editing-a process of secondary rearrangements of antigen receptor genes in autoreactive lymphocytes-is a well-established tolerance mechanism in B cells, whereas its role in T cells remains controversial. Here, we investigated this issue using a novel Tcra knock-in locus, which ensured appropriate timing of TCRα expression and allowed secondary rearrangements. Under these condi...

Microenvironmental VEGF concentration, not total dose, determines a threshold between normal and aberrant angiogenesis.

Use of long-term constitutive expression of VEGF for therapeutic angiogenesis may be limited by the growth of abnormal blood vessels and hemangiomas. We investigated the relationship between VEGF dosage and the morphology and function of newly formed blood vessels by implanting retrovirally transduced myoblasts that constitutively express VEGF164 into muscles of adult mice. Reducing VEGF dosage...

Physiological evidence that emphysema is not a feature of byssinosis.

A group of women with byssinosis of grades 2 and 3 were seen consecutively over three years in an occupational outpatient clinic. Detailed lung function tests were performed and the results for smokers and non-smokers compared. One hundred and fifty three patients were seen and 50 of these were life time non-smokers, 35 smoked one to nine cigarettes a day, and 68 smoked 10 or more cigarettes a ...